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Thoughts From The Taverna's avatar

Your articles are so good it makes me envious! You've quickly become one of my favorite follows on Substack. As always, great stuff!

DSB's avatar
5hEdited

Exceedingly interesting series. Thank you!

You wrote, "At the same time, the President threatens pharmaceutical companies with “every tool in our arsenal” if they don’t slash prices..." It caused me to think of Prevnar 20, with Pfizer making revenues of $6.4 billion in 2024 off it. The FDA emphasizes looking at absolute risk reduction (ARR) as the gold standard metric. A 2015 trial of Prevnar 13 shows the ARR rounds down to 0%. The FDA approves Prevnar 13, which as a vaccine is worthless, but makes billions for Pfizer. Interesting dilemma for Pfizer. If them, you slash the price as Trump threatens. If me, you pull the ineffective product from the market.

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